Consuming grapes may help protect against organ damage associated with the progression of metabolic syndrome, a new study has claimed. Natural components found in grapes, known as polyphenols, are thought to be responsible for its beneficial effects against metabolic syndrome, researchers found. Metabolic syndrome is a cluster of conditions that occur together – increased blood pressure, a high blood sugar level, excess body fat around the waist or low HDL (the good cholesterol) and increased blood triglycerides – significantly increasing the risk for heart disease, stroke and Type 2 diabetes. The new study, led by investigator E Mitchell Seymour, of the University of Michigan Health System, studied the effects of a high fat, American-style diet both with added grapes and without grapes (the control diet) on the heart, liver, kidneys, and fat tissue in obesity-prone rats.
The grapes – a blend of red, green and black varieties – were provided as a freeze-dried grape powder and integrated into the animals’ diets for 90 days. The results showed that three months of a grape-enriched diet significantly reduced inflammatory markers throughout the body, but most significantly in the liver and in abdominal fat tissue. Consuming grapes also reduced liver, kidney and abdominal fat weight, compared with those consuming the control diet. Additionally, grape intake increased markers of antioxidant defense, particularly in the liver and kidneys. Intake of fruits and vegetables is thought to reduce these risks, and grapes have shown benefits in multiple studies. “Our study suggests that a grape-enriched diet may play a critical role in protecting against metabolic syndrome and the toll it takes on the body and its organs,” said Seymour. “Both inflammation and oxidative stress play a role in cardiovascular disease progression and organ dysfunction in Type 2 diabetes. Grape intake impacted both of these components in several tissues which is a very promising finding,” Seymour said. The research was presented at the Experimental Biology conference in Boston.